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1

An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric, autoinhibited, and provides a model for activation

Moon, Thomas M., Sheehe, Jessica L., Nukareddy, Praveena, Nausch, Lydia W., Wohlfahrt, Jessica, Matthews, Dwight E., Blumenthal, Donald K., Dostmann, Wolfgang R.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.95 MB

english, 2018

2

Direct modulation of the protein kinase a catalytic subunit α by growth factor receptor tyrosine kinases

George B. Caldwell, Alan K. Howe, Christian K. Nickl, Wolfgang R. Dostmann, Bryan A. Ballif, Paula B. Deming

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 574 KB

english, 2012

3

Synthesis of nucleoside-3', 5'-cyclic phosphorothioates by cyclothiophosphorylation of unprotected nucleosides

Hans-Gottfried Genieser, Wolfgang Dostmann, Ulrike Bottin, Elke Butt, Bernd Jastorff

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 130 KB

english, 1988

4

(d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Iα

Christian K. Nickl, Shiv Kumar Raidas, Hong Zhao, Matthias Sausbier, Peter Ruth, Werner Tegge, Joseph E. Brayden, Wolfgang R. Dostmann

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

5

Adenosine analogue–oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIα)

Darja Lavogina, Christian K. Nickl, Erki Enkvist, Gerda Raidaru, Marje Lust, Angela Vaasa, Asko Uri, Wolfgang R. Dostmann

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 1.61 MB

english, 2010

6

Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

Wolfgang R Dostmann, Brent W Osborne

Journal:

BMC Pharmacology

Year:

2011

Language:

english

File:

PDF, 97 KB

english, 2011

7

A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Iα

Brent W Osborne, Andrew T Menke, Donald K Blumenthal, Wolfgang R Dostmann

Journal:

BMC Pharmacology

Year:

2011

Language:

english

File:

PDF, 232 KB

english, 2011

8

cGMP-dependent protein kinase from Toxoplasma gondii: functional expression in E. coli and molecular characterization

Caitlin J McFarland, Christian K Nickl, Brent W Osborne, Indra Neil Sarkar, Wolfgang R Dostmann

Journal:

BMC Pharmacology

Year:

2011

Language:

english

File:

PDF, 142 KB

english, 2011

9

Increased tissue expression and activity of cGMP-dependent protein kinase I in ANP-receptor (GC-A) – deficient mice

Ana Kilic, Sevdalina Yurukova, Stepan Gambaryan, Thomas Renné, Ulrich Walter, Melanie Voss, Wolfgang Dostmann, Michaela Kuhn

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 417 KB

english, 2005

10

Kinetics of NO-induced cyclic GMP responses in vascular smooth muscle

Sharon M Cawley, Wolfgang R Dostmann

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

11

Exploring vasomotor mechanisms using PKG specific inhibitors

Wolfgang Dostmann

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 183 KB

english, 2005

12

FlincGs: novel, non-FRET cGMP biosensors with nanomolar sensitivity for NO-induced signaling

Lydia WM Nausch, Wolfgang R Dostmann

Journal:

BMC Pharmacology

Year:

2007

Language:

english

File:

PDF, 197 KB

english, 2007

13

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

Clint L. Miller, Yujun Cai, Masayoshi Oikawa, Tamlyn Thomas, Wolfgang R. Dostmann, Manuela Zaccolo, Keigi Fujiwara, Chen Yan

Journal:

Basic Research in Cardiology

Year:

2011

Language:

english

File:

PDF, 1014 KB

english, 2011

14

The hinge region operates as a stability switch in cGMP-dependent protein kinase Iα

Arjen Scholten, Hendrik Fuß, Albert J. R. Heck, Wolfgang R. Dostmann

Journal:

Year:

2007

Language:

english

File:

PDF, 665 KB

english, 2007

15

A role for cyclic-GMP dependent protein kinase in anoikis

Yali Hou, Elsie Wong, Jessica Martin, Patricia V. Schoenlein, Wolfgang R. Dostmann, Darren D. Browning

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 284 KB

english, 2006

16

Nitric oxide-evoked transient kinetics of cyclic GMP in vascular smooth muscle cells

Sharon M. Cawley, Carolyn L. Sawyer, Kara F. Brunelle, Albert van der Vliet, Wolfgang R. Dostmann

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 1.41 MB

english, 2007

17

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

Brent W. Osborne, Jian Wu, Caitlin J. McFarland, Christian K. Nickl, Banumathi Sankaran, Darren E. Casteel, Virgil L. Woods Jr., Alexandr P. Kornev, Susan S. Taylor, Wolfgang R. Dostmann

Journal:

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

18

Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Iα

Wolfgang R.G. Dostmann, Werner Tegge, Ronald Frank, Christian K. Nickl, Mark S. Taylor, Joseph E. Brayden

Journal:

Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 699 KB

english, 2002

19

Delineation of Selective Cyclic GMP-Dependent Protein Kinase Iα Substrate and Inhibitor Peptides Based on Combinatorial Peptide Libraries on Paper

Wolfgang R.G. Dostmann, Christian Nickl, Stefan Thiel, Igor Tsigelny, Ronald Frank, Werner J. Tegge

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 4.74 MB

english, 1999

20

(Rp)- and (Sp)-8-piperidino-adenosine 3′,5′-(cyclic)thiophosphates discriminate completely between site A and B of the regulatory subunits of cAMP-dependent protein kinase type I and II

Dagfinn ØGREID, Wolfgang DOSTMANN, Hans-Gottfried GENIESER, Percy NIEMANN, Stein Ove DØSKELAND, Bernd JASTORFF

Journal:

Year:

1994

Language:

english

File:

PDF, 671 KB

english, 1994

21

Crystallization of a Deletion Mutant of the R-subunit of cAMP Dependent Protein Kinase

Ying Su, Susan S. Taylor, Wolfgang R.G. Dostmann, Nguyen H. Xuong, Kottayil I. Varughese

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 170 KB

1993

22

Ala335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I

Michaele Zorn, Kari E. Fladmark, Dagfinn Øgreid, Bernd Jastorff, Stein O. Døskeland, Wolfgang R.G. Dostmann

Journal:

Year:

1995

Language:

english

File:

PDF, 421 KB

english, 1995

23

(RP)-cAMPS inhibits the cAMP-dependent protein kinase by blocking the cAMP-induced conformational transition

Wolfgang R.G. Dostmann

Journal:

Year:

1995

Language:

english

File:

PDF, 505 KB

english, 1995

24

Expression of a chimeric, cGMP-sensitive regulatory subunit of the cAMP-depedent protein kinase type Iα

Norbert Wild, Friedrich W. Herberg, Franz Hofmann, Wolfgang R.G. Dostmann

Journal:

Year:

1995

Language:

english

File:

PDF, 699 KB

english, 1995

25

The catalytic domain of the cGMP-dependent protein kinase Iα modulates the cGMP-binding characteristics of its regulatory domain

Wolfgang R.G. Dostmann, Nicole Koep, Robert Endres

Journal:

Year:

1996

Language:

english

File:

PDF, 536 KB

english, 1996

26

Structure and physiological role of cGMP-dependent protein kinase

Franz Hofmann, Wolfgang Dostmann, Alexandra Keilbach, Wolfgang Landgraf, Peter Ruth

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1992

Language:

english

File:

PDF, 552 KB

english, 1992

27

cGMP-dependent protein kinase Iα associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake

Jennifer A Steiner, Ana Marin D Carneiro, Jane Wright, Heinrich JG Matthies, Harish C Prasad, Christian K Nicki, Wolfgang R Dostmann, Carrie C Buchanan, Jackie D Corbin, Sharron H Francis, Randy D Bla

Journal:

Molecular Brain

Year:

2009

Language:

english

File:

PDF, 1.77 MB

english, 2009

28

Active Site Mutations Define the Pathway for the Cooperative Activation of cAMP-Dependent Protein Kinase †

Herberg, Friedrich W., Taylor, Susan S., Dostmann, Wolfgang R. G.

Journal:

Year:

1996

Language:

english

File:

PDF, 364 KB

english, 1996

29

The switch helix: A putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase

Moon, Thomas M., Osborne, Brent W., Dostmann, Wolfgang R.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

30

Unfolding of the regulatory subunit of cAMP-dependent protein kinase I

Leon, Darryl A., Dostmann, Wolfgang R. G., Taylor, Susan S.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.32 MB

english, 1991

31

Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I

Dostmann, Wolfgang R. G., Taylor, Susan S.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.32 MB

english, 1991

32

Crosstalk between Domains in the Regulatory Subunit of cAMP-Dependent Protein Kinase: Influence of Amino Terminus on cAMP Binding and Holoenzyme Formation

Herberg, Friedrich W., Dostmann, Wolfgang R. G., Zorn, Michaela, Davis, Shirley J., Taylor, Susan S.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.92 MB

english, 1994

33

Role of magnesium-ATP in the activation and reassociation of cAMP-dependent protein kinase I: consequences of replacing the essential arginine in cAMP-binding site A

Neitzel, James J., Dostmann, Wolfgang R. G., Taylor, Susan S.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.95 MB

english, 1991

34

Determination of Cyclic Nucleotide-Dependent Protein Kinase Substrate Specificity by the Use of Peptide Libraries on Cellulose Paper

Tegge, Werner, Frank, Ronald, Hofmann, Franz, Dostmann, Wolfgang R. G.

Journal:

Year:

1995

Language:

english

File:

PDF, 3.59 MB

english, 1995

35

Handbook of Cell Signaling || Inhibitors of Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases

Dostmann, Wolfgang R.

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

36

Altered cGMP Dynamics at the Plasma Membrane Contribute to Diarrhea in Ulcerative Colitis

Arora, Kavisha, Sinha, Chandrima, Zhang, Weiqiang, Moon, Chang Suk, Ren, Aixia, Yarlagadda, Sunitha, Dostmann, Wolfgang R., Adebiyi, Adebowale, Haberman, Yael, Denson, Lee A., Wang, Xusheng, Naren, An

Journal:

The American Journal of Pathology

Year:

2015

Language:

english

File:

PDF, 2.66 MB

english, 2015

37

Nitric Oxide Promotes Airway Epithelial Wound Repair through Enhanced Activation of MMP-9

Bove, Peter F., Wesley, Umadevi V., Greul, Anne-Katrin, Hristova, Milena, Dostmann, Wolfgang R., van der Vliet, Albert

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.27 MB

english, 2007

38

Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors

Andrew M. Batchelor, Katalin Bartus, Clare Reynell, Sophie Constantinou, Edward J. Halvey, Kara F. Held, Wolfgang R. Dostmann, Jeffrey Vernon, John Garthwaite and Louis J. Ignarro

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

39

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα

Moon, Thomas M., Tykocki, Nathan R., Sheehe, Jessica L., Osborne, Brent W., Tegge, Werner, Brayden, Joseph E., Dostmann, Wolfgang R.

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 1.83 MB

english, 2015

40

Inhibition of cGMP-Dependent Protein Kinase Reverses Phenotypic Modulation of Vascular Smooth Muscle Cells

Dey, Nupur B, Foley, Kevin F, Lincoln, Thomas M, Dostmann, Wolfgang R

Journal:

Journal of Cardiovascular Pharmacology

Year:

2005

Language:

english

File:

PDF, 677 KB

english, 2005

41

Isoleucine 368 is involved in low-affinity binding of N 6 -modified cAMP analogues to site B of the regulatory subunit of cAMP-dependent protein kinase I

HUQ, Ikramul, DOSTMANN, Wolfgang R. G., ØGREID, Dagfinn

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

42

Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle

Held, Kara F., Dostmann, Wolfgang R.

Journal:

Frontiers in Pharmacology

Year:

2012

Language:

english

File:

PDF, 2.36 MB

english, 2012

43

Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase

Sheehe, Jessica L., Bonev, Adrian D., Schmoker, Anna M., Ballif, Bryan A., Nelson, Mark T., Moon, Thomas M., Dostmann, Wolfgang R.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

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